Jagadish K, Patwari A K, Sarin S K, Prakash C, Srivastava D K, Anand V K
Department of Pediatrics, Lady Hardinge Medical College, New Delhi.
Indian Pediatr. 1994 Jul;31(7):807-11.
Thirty one children with typhoid fever aged 2 months to 12 years and blood culture positive for multidrug resistant S. typhi were prospectively studied for their hepatic functions at the time of hospitalization and 2-3 weeks after completion of antibiotic therapy. Hepatic manifestations included hepatomegaly (51.6%); jaundice (16.1%); raised levels of serum glutamic oxaloacetic transaminase (SGOT) (61.3%), serum glutamic pyruvic transaminase (SGPT) (48.4%), alkaline phosphatase (AP) (22.6%) and serum bilirubin (SB) (6.1%); reduced levels of serum albumin (SA) (41.9%); prolonged prothrombin time (PT) (9.7%) and abnormal ultrasound abdomen (19.3%). Hepatic dysfunction was a notable feature even in those cases without hepatomegaly, with raised levels of SGOT (60%), SGPT (40%), AP (20%), SB (6.7%), decreased SA (53.3%) and prolonged PT (6.7%). There was no correlation between the degree of hepatic enlargement or hyperbilirubinemia with abnormalities in liver functions. Hepatic dysfunction was noticed to be transient, as all these parameters returned to normal within 2-3 weeks after successful antibiotic therapy.
对31名年龄在2个月至12岁之间、血培养显示多重耐药伤寒杆菌阳性的伤寒患儿，在住院时以及抗生素治疗结束后2 - 3周对其肝功能进行了前瞻性研究。肝脏表现包括肝肿大（51.6%）；黄疸（16.1%）；血清谷草转氨酶（SGOT）水平升高（61.3%）、血清谷丙转氨酶（SGPT）水平升高（48.4%）、碱性磷酸酶（AP）水平升高（22.6%）以及血清胆红素（SB）水平升高（6.1%）；血清白蛋白（SA）水平降低（41.9%）；凝血酶原时间（PT）延长（9.7%）以及腹部超声异常（19.3%）。即使在那些没有肝肿大的病例中，肝功能障碍也是一个显著特征，SGOT水平升高（60%）、SGPT水平升高（40%）、AP水平升高（20%）、SB水平升高（6.7%）、SA降低（53.3%）以及PT延长（6.7%）。肝脏肿大程度或高胆红素血症与肝功能异常之间没有相关性。肝功能障碍被发现是短暂的，因为在成功的抗生素治疗后2 - 3周内所有这些参数都恢复了正常。
