Mizokami M, Lau J Y, Suzuki K, Nakano T, Gojobori T
Second Department of Medicine, Nagoya City University, Japan.
J Hepatol. 1994 Nov;21(5):884-6. doi: 10.1016/s0168-8278(94)80254-8.
The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-alpha therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-alpha therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-alpha therapy. However, only group 3 remained after interferon-alpha therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-alpha.
在一名接受α干扰素治疗的慢性丙型肝炎病毒感染患者中，对丙型肝炎病毒的准种性质进行了研究。扩增并克隆了丙型肝炎病毒E2/NS1区域，并在α干扰素治疗前后对多个克隆进行了测序。通过系统发育树分析，丙型肝炎病毒准种可分为三组。在α干扰素治疗前，所有组的准种均存在。然而，α干扰素治疗后仅保留了第3组。此外，在早期生化复发期间仅存在第3组丙型肝炎病毒准种。这些数据表明，丙型肝炎病毒准种的不同组对α干扰素可能具有不同的敏感性。
