Davis C P, Torre P R, Williams C, Gray C, Barrett K, Krucke G, Peake D, Bass B
Department of Surgery, University of Texas Medical Branch, Galveston 77555-1073.
Am J Emerg Med. 1995 Mar;13(2):146-50. doi: 10.1016/0735-6757(95)90081-0.
This study was designed to compare and contrast the speed and efficacy of meperidine (75 mg)/promethazine (25 mg) intramuscularly to ketorolac (60 mg) intramuscularly, in a double-blind study in reducing the symptoms of migraine headache. Forty-two patients who presented to the emergency department between July 1992 and February 1993, with previous diagnoses of migraine headache, were considered for this study. Patients subjectively evaluated parameters of their migraine headaches (eg, pain and nausea) using a numeric scale and were later asked to reevaluate these same parameters at 30, 60, and 360 minutes after a single intramuscular injection of either ketorolac (60 mg) or meperidine (75 mg)/promethazine (25 mg). Sixty-eight percent of patients given meperidine/promethazine responded whereas 55% of patients given ketorolac responded. The responder group showed a statistically significant reduction in headache within 30 minutes with both drug regimens. There was no statistically significant difference between the number of responders in either group. The responders from both groups had relief that lasted 6 hours after injection. In the nonresponder groups, most of the patients withdrew within 1 hour after treatment. As determined by patient response to treatment of their migraine headaches, there was no statistically significant difference between the ketorolac and the meperidine/promethazine groups.
本研究旨在通过一项双盲研究，比较和对比哌替啶（75毫克）/异丙嗪（25毫克）肌肉注射与酮咯酸（60毫克）肌肉注射在减轻偏头痛症状方面的速度和疗效。1992年7月至1993年2月期间到急诊科就诊、先前被诊断为偏头痛的42名患者被纳入本研究。患者使用数字量表主观评估偏头痛的参数（如疼痛和恶心），并在单次肌肉注射酮咯酸（60毫克）或哌替啶（75毫克）/异丙嗪（25毫克）后30、60和360分钟重新评估这些相同参数。接受哌替啶/异丙嗪治疗的患者中有68%有反应，而接受酮咯酸治疗的患者中有55%有反应。两组治疗方案均使有反应的患者组在30分钟内头痛明显减轻。两组中有反应者的数量无统计学显著差异。两组中有反应者注射后缓解持续6小时。在无反应组中，大多数患者在治疗后1小时内退出。根据患者对偏头痛治疗的反应确定，酮咯酸组和哌替啶/异丙嗪组之间无统计学显著差异。
