Huang N E, Chakraborty R, Budowle B
Criminal Investigation Bureau DNA Laboratory, Taipei, Taiwan, Republic of China.
Int J Legal Med. 1994;107(3):118-20. doi: 10.1007/BF01225597.
Allele frequencies for the VNTR locus D1S80 were determined in a Chinese population sample using the polymerase chain reaction and subsequent analysis of the amplified products by polyacrylamide gel electrophoresis and silver staining. A total of 18 nominal D1S80 alleles were observed in 105 unrelated Chinese. The data demonstrate that D1S80 is highly polymorphic in Chinese with a heterozygosity of 90.5%. The D1S80 frequency distribution meets Hardy-Weinberg expectations. This D1S80 data can be used in forensic analyses and paternity tests to estimate the frequency of a DNA profile in a Chinese population.
使用聚合酶链反应并通过聚丙烯酰胺凝胶电泳和银染对扩增产物进行后续分析，在中国人群样本中确定了VNTR基因座D1S80的等位基因频率。在105名无亲缘关系的中国人中总共观察到18种名义上的D1S80等位基因。数据表明，D1S80在中国人群中具有高度多态性，杂合度为90.5%。D1S80频率分布符合哈迪-温伯格预期。该D1S80数据可用于法医分析和亲子鉴定，以估计中国人群中DNA图谱的频率。
