精神分裂症患者治疗前后催乳素和促甲状腺激素对促甲状腺激素释放激素及氟哌啶醇的反应。

Prolactin and TSH responses to TRH and to haloperidol in schizophrenic patients before and after treatment.

作者信息

Markianos M, Hatzimanolis J, Stefanis C

机构信息

Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece.

出版信息

Eur Neuropsychopharmacol. 1994 Dec;4(4):513-6. doi: 10.1016/0924-977x(94)90300-x.

DOI:10.1016/0924-977x(94)90300-x

PMID:7894262

Abstract

The prolactin (PRL) and the TSH responses to thyrotropin releasing hormone (TRH, 0.4 mg i.v.) and to haloperidol (5 mg i.m.) were studied in 11 male schizophrenic patients in a drug-free state and after treatment with haloperidol, 60 mg daily. The PRL responses observed after i.m. haloperidol in the drug-free state, on average 35.4 ng/ml, were abolished after treatment, indicating complete receptor blockade, while the PRL responses to TRH were preserved, although moderately reduced (from 19.4 to 14.8 ng/ml on average). The TSH responses to TRH were unaltered by the treatment (means 8.25 and 7.74 mIU/l). The results show that the TSH and partially the PRL releasing actions of TRH are not mediated via receptors that are effectively blocked by haloperidol.

摘要

对11名处于未服药状态的男性精神分裂症患者以及在接受每日60毫克氟哌啶醇治疗后，研究了催乳素（PRL）和促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH，静脉注射0.4毫克）和氟哌啶醇（肌肉注射5毫克）的反应。在未服药状态下肌肉注射氟哌啶醇后观察到的PRL反应，平均为35.4纳克/毫升，治疗后消失，表明受体被完全阻断，而对TRH的PRL反应得以保留，尽管有所适度降低（平均从19.4降至14.8纳克/毫升）。治疗后TSH对TRH的反应未改变（平均值分别为8.25和7.74毫国际单位/升）。结果表明，TRH的TSH释放作用以及部分PRL释放作用并非通过被氟哌啶醇有效阻断的受体介导。