Markianos M, Hatzimanolis J, Stefanis C
Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece.
Eur Neuropsychopharmacol. 1994 Dec;4(4):513-6. doi: 10.1016/0924-977x(94)90300-x.
The prolactin (PRL) and the TSH responses to thyrotropin releasing hormone (TRH, 0.4 mg i.v.) and to haloperidol (5 mg i.m.) were studied in 11 male schizophrenic patients in a drug-free state and after treatment with haloperidol, 60 mg daily. The PRL responses observed after i.m. haloperidol in the drug-free state, on average 35.4 ng/ml, were abolished after treatment, indicating complete receptor blockade, while the PRL responses to TRH were preserved, although moderately reduced (from 19.4 to 14.8 ng/ml on average). The TSH responses to TRH were unaltered by the treatment (means 8.25 and 7.74 mIU/l). The results show that the TSH and partially the PRL releasing actions of TRH are not mediated via receptors that are effectively blocked by haloperidol.
对11名处于未服药状态的男性精神分裂症患者以及在接受每日60毫克氟哌啶醇治疗后，研究了催乳素（PRL）和促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH，静脉注射0.4毫克）和氟哌啶醇（肌肉注射5毫克）的反应。在未服药状态下肌肉注射氟哌啶醇后观察到的PRL反应，平均为35.4纳克/毫升，治疗后消失，表明受体被完全阻断，而对TRH的PRL反应得以保留，尽管有所适度降低（平均从19.4降至14.8纳克/毫升）。治疗后TSH对TRH的反应未改变（平均值分别为8.25和7.74毫国际单位/升）。结果表明，TRH的TSH释放作用以及部分PRL释放作用并非通过被氟哌啶醇有效阻断的受体介导。
