关于白细胞介素4、6和10及其在常见可变免疫缺陷中与免疫球蛋白G和M的相互关系。

On interleukins 4, 6 and 10 and their interrelationship with immunoglobulins G and M in common variable immunodeficiency.

作者信息

Fritsch A, Junker U, Vogelsang H, Jager L

机构信息

Institute of Clinical Immunology, F.-Schiller-University, Jena, Germany.

出版信息

Cell Biol Int. 1994 Nov;18(11):1067-75. doi: 10.1006/cbir.1994.1030.

DOI:10.1006/cbir.1994.1030

PMID:7894390

Abstract

Following culture of human peripheral blood mononuclear cells (PBMNC) from 25 normal donors and 15 patients with common variable immunodeficiency (CVID), we were unable to identify any IL10-defective patients. Clear-cut effects of IL4 could be demonstrated in controls, while in CVID all effects are less pronounced. While in both controls and CVID baseline levels of IL6, IgG and IgM were found to be correlated, this was altered by the addition of either IL4 or Poke Weed Mitogen (PWM). We therefore conclude that the inability of PBMNC to produce IL10 is not the cause of CVID in our patients. In CVID, the regulating circuitry triggered by IL4 remains principally intact, however, some subgroups of CVID behave significantly differently.

摘要

在对25名正常供体和15名常见变异型免疫缺陷（CVID）患者的人外周血单个核细胞（PBMNC）进行培养后，我们未能识别出任何白细胞介素10（IL10）缺陷患者。在对照组中可证明白细胞介素4（IL4）有明确的作用，而在CVID患者中所有作用都不那么明显。虽然在对照组和CVID患者中均发现白细胞介素6（IL6）、免疫球蛋白G（IgG）和免疫球蛋白M（IgM）的基线水平相关，但添加IL4或商陆有丝分裂原（PWM）后这种相关性发生了改变。因此我们得出结论，PBMNC不能产生IL10并非我们这些患者患CVID的原因。在CVID中，由IL4触发的调节回路基本保持完整，然而，CVID的一些亚组表现出显著不同。