Ticher A, Sackett-Lundeen L, Ashkenazi I E, Haus E
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel.
Chronobiol Int. 1994 Dec;11(6):349-55. doi: 10.3109/07420529409057252.
Most human variables exhibit rhythms with an about 24 hour (circadian) period. Each rhythm can be characterized by its acrophase (calculated peak time of the cosine curve best fitting to the data), its amplitude and rhythm adjusted mean (MESOR). The sequential array of the rhythms' acrophases represents the temporal order of the human time structure. In the present work we used circadian rhythms of 24 chemical and 15 hormonal variables extracted from published studies which were done in a defined area of southeastern Europe (Romania). All studies had a comparable experimental design and were analyzed biochemically and statistically in the same laboratory. The acrophases of these rhythms obtained from both genders of different age groups (from the 2nd to the 9th decade of age) were subjected to multiple correlation test, cluster and principal coordinates analyses. The results show that the temporal order is affected both by gender and age, and evaluate the degree of the effect, offer a "chronbiologic fingerprint" for the examined groups and assist in dissecting rhythm variability among populations.
大多数人体变量呈现出约24小时（昼夜节律）周期的节律。每种节律都可以通过其峰相位（根据最适合数据的余弦曲线计算出的峰值时间）、振幅和节律调整均值（MESOR）来表征。节律峰相位的序列排列代表了人体时间结构的时间顺序。在本研究中，我们使用了从已发表的研究中提取的24种化学变量和15种激素变量的昼夜节律，这些研究是在东南欧（罗马尼亚）的一个特定区域进行的。所有研究都有可比的实验设计，并在同一实验室进行生化和统计分析。对来自不同年龄组（从2岁到90岁）的男女的这些节律的峰相位进行多重相关性测试、聚类分析和主坐标分析。结果表明，时间顺序受性别和年龄的影响，并评估了影响程度，为受检群体提供了一种“生物钟指纹”，并有助于剖析不同人群之间的节律变异性。
