Arbab A S, Koizumi K, Uchiyama G, Arai T
Department of Radiology, Yamanashi Medical University, Japan.
Clin Nucl Med. 1995 Jan;20(1):5-12. doi: 10.1097/00003072-199501000-00002.
The usefulness of combined Tc-99m and Ga-67 scans in diagnosing salivary gland disorders was evaluated in a total of 31 patients. Out of 6 patients with Warthin's tumor, 4 showed a typical pattern of high-activity in the gland with retention of Tc-99m, but without an affinity for Ga-67. Out of 9 patients with pleomorphic adenoma, 8 showed a "cold" area in the tumor by Tc-99m and 5 of the 9 patients had accumulated Ga-67. Five of 6 patients with malignant tumor showed an affinity for Ga-67. Nine of 10 patients with sialadenitis showed diffuse uptake of both Tc-99m and Ga-67 in the involved gland. Combined Tc-99m and Ga-67 imaging was useful in detecting the cases of Warthin's tumor and sialadenitis (90% sensitivity and 89% specificity for sialadenitis), but the study had limitations in differentiating malignant tumors from benign tumors (66% sensitivity and 84% specificity). However, Ga-67 imaging showed a 91% negative predictive value. A negative scan could almost rule out the possibility of malignant disease of the salivary gland.
对31例患者评估了联合使用锝-99m（Tc-99m）和镓-67（Ga-67）扫描诊断唾液腺疾病的效用。在6例沃辛瘤患者中，4例显示腺体呈典型的高活性模式，Tc-99m滞留，但对Ga-67无亲和力。在9例多形性腺瘤患者中，8例在Tc-99m扫描时肿瘤呈现“冷”区，9例患者中有5例Ga-67聚集。6例恶性肿瘤患者中有5例对Ga-67有亲和力。10例涎腺炎患者中有9例在受累腺体中显示Tc-99m和Ga-67均呈弥漫性摄取。联合Tc-99m和Ga-67显像有助于检测沃辛瘤和涎腺炎病例（涎腺炎的敏感性为90%，特异性为89%），但该研究在鉴别恶性肿瘤与良性肿瘤方面存在局限性（敏感性为66%，特异性为84%）。然而，Ga-67显像显示阴性预测值为91%。阴性扫描几乎可以排除唾液腺恶性疾病的可能性。
