[激活性素对慢性骨髓增殖性疾病中血液淋巴细胞细胞毒性的影响]
[Effect of tactivin on cytotoxicity of blood lymphocytes in chronic myeloproliferative diseases].
作者信息
Guseva S A
出版信息
Gematol Transfuziol. 1994 Sep-Oct;39(5):22-5.
The author studied natural cellular cytotoxicity (NCC) and antibody-dependent cytotoxicity (ADC) in lymphocytes from 31 patients with chronic myeloid leukemia (CML) and 37 patients with subleukemic myeloleukemia (SLM) in active clinical stage. The above parameters were found low in both diseases. Cytostatic therapy for CML did not affect NCC, but inhibited ADC. SLM treatment with myelobromol inhibited both cytotoxic responses. Combined therapy with adjuvant tactivin stimulated cytotoxic reactions activity. Tactivin positive effects persisted for two months.
作者研究了31例慢性粒细胞白血病（CML）患者和37例处于临床活动期的亚白血病性骨髓白血病（SLM）患者淋巴细胞中的自然细胞毒性（NCC）和抗体依赖性细胞毒性（ADC）。发现上述参数在两种疾病中均较低。CML的细胞抑制疗法不影响NCC，但抑制ADC。用马利兰治疗SLM可抑制两种细胞毒性反应。辅助性促有丝分裂素原联合治疗可刺激细胞毒性反应活性。促有丝分裂素原的积极作用持续了两个月。
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