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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Viglione P N, Gomez C, Pinto J E

Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Gen Pharmacol. 1994 Nov;25(7):1445-9. doi: 10.1016/0306-3623(94)90172-4.

The effects of the increase of osmotic strength on extracellular pH modifications produced during buffer-free, 5 mM Ba2+ stimulation was studied in decorticated perfused bovine adrenal glands. 2. A pronounced and reversible attenuation of the extracellular pH drop as well as of the release of catecholamines induced by Ba2+ was detected in glands exposed to a hyperosmotic (750 mOsm) perfusion fluid made up by the addition of NaCl. 3. Similar results were observed using sucrose as osmoticant instead of NaCl. 4. A progressive decline in both external acidification and secretory response to Ba2+ was found on gradually increasing the osmotic strength of the perfusion fluid. 5. These results provide additional evidence in favour of the existence of a close association between extracellular acidification and adrenomedullary secretion induced by buffer-free Ba2+.

在去皮质灌注的牛肾上腺中，研究了渗透压升高对无缓冲液、5 mM Ba2+刺激期间产生的细胞外pH变化的影响。2. 在暴露于通过添加NaCl制成的高渗（750 mOsm）灌注液的腺体中，检测到Ba2+诱导的细胞外pH下降以及儿茶酚胺释放的明显且可逆的减弱。3. 使用蔗糖代替NaCl作为渗透压剂时观察到了类似结果。4. 随着灌注液渗透压强度逐渐增加，发现对Ba2+的外部酸化和分泌反应均逐渐下降。5. 这些结果为细胞外酸化与无缓冲液Ba2+诱导的肾上腺髓质分泌之间存在密切关联提供了更多证据。

Viglione P N, Gomez C, Pinto J E

Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Gen Pharmacol. 1994 Nov;25(7):1445-9. doi: 10.1016/0306-3623(94)90172-4.

The effects of the increase of osmotic strength on extracellular pH modifications produced during buffer-free, 5 mM Ba2+ stimulation was studied in decorticated perfused bovine adrenal glands. 2. A pronounced and reversible attenuation of the extracellular pH drop as well as of the release of catecholamines induced by Ba2+ was detected in glands exposed to a hyperosmotic (750 mOsm) perfusion fluid made up by the addition of NaCl. 3. Similar results were observed using sucrose as osmoticant instead of NaCl. 4. A progressive decline in both external acidification and secretory response to Ba2+ was found on gradually increasing the osmotic strength of the perfusion fluid. 5. These results provide additional evidence in favour of the existence of a close association between extracellular acidification and adrenomedullary secretion induced by buffer-free Ba2+.

在去皮质灌注的牛肾上腺中，研究了渗透压升高对无缓冲液、5 mM Ba2+刺激期间产生的细胞外pH变化的影响。2. 在暴露于通过添加NaCl制成的高渗（750 mOsm）灌注液的腺体中，检测到Ba2+诱导的细胞外pH下降以及儿茶酚胺释放的明显且可逆的减弱。3. 使用蔗糖代替NaCl作为渗透压剂时观察到了类似结果。4. 随着灌注液渗透压强度逐渐增加，发现对Ba2+的外部酸化和分泌反应均逐渐下降。5. 这些结果为细胞外酸化与无缓冲液Ba2+诱导的肾上腺髓质分泌之间存在密切关联提供了更多证据。