Espeso E A, Fernández-Cañón J M, Peñalva M A
Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas del C.S.I.C., Madrid, Spain.
FEMS Microbiol Lett. 1995 Feb 1;126(1):63-7. doi: 10.1016/0378-1097(94)00527-x.
Transcription of the Aspergillus nidulans ipnA gene is under carbon regulation. Loss-of-function mutations in creB or creC do not cause full derepression of ipnA transcript levels in sucrose-grown mycelia and do not elevate repressed penicillin levels, indicating that neither of these genes plays a major regulatory role in penicillin biosynthesis. However, these mutations reduce external pH acidification, accelerate sucrose degradation and result in extracellular accumulation of resulting D-glucose and D-fructose. These effects would explain the partial elevation of carbon-repressed ipnA transcript levels observed in strains carrying creB- or creC- mutations.
