Genetic control of development in Xenopus laevis.

In this paper we address the question of how genes can control development by using Xenopus as a model system, since it combines the classical advantages of amphibian embryology with advanced molecular techniques. Several developmental regulator genes have been shown to encode for transcription factors which trigger the activation of downstream genes, thus resulting in a cascade of regulatory events. In the first two examples, we deal with regulatory events that underlie early body patterning in vertebrates, and with the role of homeobox transcription factors in deciphering positional information along the body axis. In the third example, we address the question of the role of post-transcriptional regulation in development by studying the possible regulatory role of a cytoplasmic zinc finger protein, presumably acting through RNA-protein interactions. The general idea is that understanding how genes can control development will hopefully lead to understanding the construction of a shape, and eventually of an organism.