Maglaveras N, Offner F, van Capelle F J, Allessie M A, Sahakian A V
Aristotelian University of Thessaloniki, Macedonia, Greece.
J Electrocardiol. 1995 Jan;28(1):17-31. doi: 10.1016/s0022-0736(05)80004-4.
A two-dimensional anisotropic model of cardiac ventricular muscle was used to study the effects of discontinuities (barriers), such as dead cells or high-resistance areas, on longitudinal plane-wave propagation. Problems in propagation appear when long barriers become thicker and their spacing closer. Short barriers with large widths and small spacing also cause propagation disturbances and significant delays in their vicinity. If the plane wave front propagates through the barriers, the velocity returns to near normal within one-length constant away from the end of the barrier region. For a funnel-like structure, an opening of 13 cells should exist for longitudinal plane wave propagation. For smaller openings, the ratio of openings required for propagation to occur when traveling from a narrow to a wider area of tissue is proportional to the anisotropy ratio, which can cause unidirectional block. Tortuosity, created by spatial distribution of dead cell barriers, can facilitate propagation by changing the effective impedance the wave front sees, and can create multiple local delays, which may result in discrepancies when measuring propagation velocity.
使用二维各向异性心室肌模型研究诸如死细胞或高电阻区域等不连续（屏障）对纵向平面波传播的影响。当长屏障变厚且间距变小时，传播会出现问题。宽间距且窄宽度的短屏障也会在其附近引起传播干扰和显著延迟。如果平面波前传播通过屏障，在距屏障区域末端一个长度常数范围内速度会恢复到接近正常。对于漏斗状结构，纵向平面波传播需要13个细胞的开口。对于较小的开口，从组织的窄区域传播到宽区域时发生传播所需的开口比例与各向异性比例成正比，这可能导致单向阻滞。由死细胞屏障的空间分布造成的曲折度可通过改变波前所见的有效阻抗来促进传播，并可产生多个局部延迟，这在测量传播速度时可能导致差异。
