Seppälä M T, Haltia M J, Sankila R J, Jääskeläinen J E, Heiskanen O
Department of Neurosurgery, Helsinki University Hospital, Finland.
J Neurosurg. 1995 Apr;82(4):572-7. doi: 10.3171/jns.1995.82.4.0572.
Spinal neurofibromas are uncommon, comprising approximately 3% of all spinal tumors. They occur both sporadically and in association with neurofibromatosis 1 (NF1; von Recklinghausen's disease). This study presents the clinical characteristics of 32 patients who underwent surgery for symptomatic spinal neurofibromas. Twenty-two of these patients showed clinical signs of NF1. The patients were typically younger (median age 31 years) than those with spinal schwannomas. The tumors were located mainly in the cervical region and tended to grow both extra- and intradurally. Patients with NF1 were prone to develop new spinal neurofibromas. A life-table analysis showed a reduced survival rate for these patients compared to that of the general population.
脊髓神经纤维瘤并不常见，约占所有脊髓肿瘤的3%。它们既可散发出现，也可与神经纤维瘤病1型（NF1；冯雷克林霍增氏病）相关。本研究呈现了32例因有症状的脊髓神经纤维瘤而接受手术治疗患者的临床特征。其中22例患者有NF1的临床体征。这些患者通常比患有脊髓神经鞘瘤的患者更年轻（中位年龄31岁）。肿瘤主要位于颈部区域，倾向于在硬膜外和硬膜内生长。患有NF1的患者易于出现新的脊髓神经纤维瘤。生存分析表明，与普通人群相比，这些患者的生存率降低。
