Kodama H, Yoshida I, Ohtani Y, Ishikawa S, Ohtaki A, Takahashi T, Satoh Y, Kawashima O, Morishita Y
Second Department of Surgery, Gunma University, Maebashi, Japan.
Kyobu Geka. 1995 Feb;48(2):110-2.
Five patients with myasthenia gravis whose condition declined during the postoperative unstable period were studied. The Osserman's type, age at the time of onset, duration of illness, sex, age at the time of surgery, preoperative steroid therapy, thymoma and acetyl choline receptor antibody titers were compared with those of 21 patients (control) with myasthenia gravis who had an uneventful postoperative course. In comparison, the study group's Osserman's type was slight, age at the time of onset was older (p < 0.05) and duration of illness was shorter (p < 0.05). There was no significant difference between the groups in sex, age at the time of surgery, thymoma and acetyl choline receptor antibody titers. None of them had preoperative steroid therapy. Intensive postoperative management and careful follow-up at the postoperative unstable period are necessary particularly for patients who have slight Osserman's type, old age at the time of onset, short duration of illness and no preoperative steroid therapy.
对5例在术后不稳定期病情恶化的重症肌无力患者进行了研究。将这些患者的奥氏分型、发病年龄、病程、性别、手术年龄、术前类固醇治疗、胸腺瘤及乙酰胆碱受体抗体滴度与21例术后病程平稳的重症肌无力患者（对照组）进行比较。结果显示，研究组奥氏分型较轻，发病年龄较大（p<0.05），病程较短（p<0.05）。两组在性别、手术年龄、胸腺瘤及乙酰胆碱受体抗体滴度方面无显著差异。他们均未接受术前类固醇治疗。特别是对于奥氏分型较轻、发病年龄较大、病程较短且未接受术前类固醇治疗的患者，术后不稳定期进行强化管理和仔细随访是必要的。
