Husby G, van de Rijn I, Zabriskie J B, Abdin Z H, Williams R C
J Exp Med. 1976 Oct 1;144(4):1094-110. doi: 10.1084/jem.144.4.1094.
46% of sera from 30 children with rheumatic chorea showed IgG antibody reacting with neuronal cytoplasm of human caudate and subthalamic nuclei. The antibody was also detected in 14% of 50 children with active rheumatic carditis. 55 normal control sera, as well as 148 sera from a broad variety of other disease states showed a low prevalence (1.8-4.0%) of positive reactions. In rheumatic chorea the presence of anti-neuronal antibody appeared to correlate with severity and duration of clinical attacks. Antibody reacting with neuronal cytoplasm was completely removed by absorption with Group A streptococcal membranes or with isolated human neurons from caudate nucleus. Partial absorption of antibody was also recorded using Group A cell wall preparations but not with Group A carbohydrate. No absorption of positive reactions was seen with streptococcal Group D membranes or cell walls. In rheumatic chorea, anti-neuronal antibody appeared to represent cross-reaction with antigens shared by Group A streptococcal membranes.
30例风湿性舞蹈病患儿的血清中，46%显示IgG抗体与人尾状核和丘脑底核的神经元细胞质发生反应。在50例活动性风湿性心脏病患儿中，14%也检测到了该抗体。55份正常对照血清以及148份来自各种其他疾病状态的血清显示阳性反应的患病率较低（1.8 - 4.0%）。在风湿性舞蹈病中，抗神经元抗体的存在似乎与临床发作的严重程度和持续时间相关。与神经元细胞质发生反应的抗体通过用A组链球菌膜或从尾状核分离的人神经元进行吸收而被完全去除。使用A组细胞壁制剂也记录到了抗体的部分吸收，但用A组碳水化合物则没有。用D组链球菌膜或细胞壁未观察到阳性反应的吸收。在风湿性舞蹈病中，抗神经元抗体似乎代表了与A组链球菌膜共有的抗原的交叉反应。
