Agrawal S
Department of Surgery, Tata Memorial Hospital, Bombay, India.
J Surg Oncol. 1995 Mar;58(3):168-72. doi: 10.1002/jso.2930580306.
The diagnostic accuracy of fine needle aspiration cytology (FNAC) was evaluated in thyroid nodules in 100 consecutive cases, who subsequently underwent thyroidectomy between the years 1989-1991. FNAC as a diagnostic test for thyroid nodules demonstrated an accuracy of 90.9%, a sensitivity of 76.5%, a specificity of 95.9% with a false positivity of 2%, false negativity of 4%, positive and negative predictive values of 86.7% and 92.2%, respectively. A correct classification of the carcinoma type on the basis of FNAC was possible only in 69% patients. As a result, FNAC is the first line of investigation in most nontoxic nodular goiters and often the only procedure necessary to obtain an accurate diagnosis. However, it is recommended only as an adjunct to clinical judgment and is not intended to replace it.
对1989年至1991年间连续100例随后接受甲状腺切除术的甲状腺结节患者进行了细针穿刺细胞学检查（FNAC）的诊断准确性评估。FNAC作为甲状腺结节的诊断测试，显示准确率为90.9%，敏感性为76.5%，特异性为95.9%，假阳性率为2%，假阴性率为4%，阳性和阴性预测值分别为86.7%和92.2%。仅69%的患者能够根据FNAC对癌型进行正确分类。因此，FNAC是大多数非毒性结节性甲状腺肿的一线检查方法，并且通常是获得准确诊断所需的唯一程序。然而，建议仅将其作为临床判断的辅助手段，并不打算取代临床判断。
