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硫代葡萄糖金处理家兔脑单胺的组织化学荧光研究

Histochemical fluorescence studies of brain monoamines in goldthioglucose-treated rabbits.

作者信息

Ishizaki F

出版信息

J Neural Transm. 1976;39(3):223-9. doi: 10.1007/BF01256511.

DOI:10.1007/BF01256511
PMID:789820
Abstract

Fluorescence histochemical experiment of brain monoamines and chemical analysis of brain 5-hydroxytryptamine (5-HT) in goldthioglucose (GTG)-treated rabbits were performed. The fluorescence of brain catecholamines (CA) and 5-HT were strengthened in intensity until first week after treatment and reduced from second week. Body weight in GTG-treated rabbits showed decreasing tendency in the period when monoamine fluorescence was strengthened and increased when monoamine fluorescence was lowered in intensity. Content of brain 5-HT second day after treatment showed an increasing tendency in the cortex. In comparison with EEG findings by Matsumura, it is speculated that there is correspondence between slow wave in EEG and increased fluorescence of brain monoamines and between spiky and decreased fluorescence.

摘要

对经硫代葡萄糖金(GTG)处理的家兔进行了脑单胺的荧光组织化学实验以及脑5-羟色胺(5-HT)的化学分析。脑儿茶酚胺(CA)和5-HT的荧光强度在处理后的第一周增强,从第二周开始减弱。GTG处理的家兔体重在单胺荧光增强期间呈下降趋势,而在单胺荧光强度降低时则增加。处理后第二天,大脑皮质中5-HT的含量呈增加趋势。与松村的脑电图结果相比,推测脑电图中的慢波与脑单胺荧光增强之间存在对应关系,而棘波与荧光减弱之间也存在对应关系。

相似文献

1
Histochemical fluorescence studies of brain monoamines in goldthioglucose-treated rabbits.硫代葡萄糖金处理家兔脑单胺的组织化学荧光研究
J Neural Transm. 1976;39(3):223-9. doi: 10.1007/BF01256511.
2
Effects of goldthioglucose lesions on central catecholamine levels in the mouse.金硫葡萄糖损伤对小鼠中枢儿茶酚胺水平的影响。
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3
Goldthioglucose causes brain norepinephrine and serotonin depletion correlated with increased body weight.金硫葡萄糖会导致大脑去甲肾上腺素和血清素耗竭,这与体重增加相关。
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4
Association of altered brain norephinephrine and serotonin with the obesity induced by goldthioglucose in mice.脑去甲肾上腺素和血清素改变与小鼠硫代葡萄糖金诱导的肥胖之间的关联。
Pharmacol Biochem Behav. 1978 Jul;9(1):123-8. doi: 10.1016/0091-3057(78)90022-9.
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Goldthioglucose-induced lesions and quantitative changes of monoamines in the rat brain.金硫葡萄糖诱导的大鼠脑内损伤及单胺类物质的定量变化
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Behav Neural Biol. 1980 Mar;28(3):300-18. doi: 10.1016/s0163-1047(80)92301-8.
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Effects of estrogen upon hypothalamic vulnerability to goldthioglucose in mice.雌激素对小鼠下丘脑对金硫葡萄糖易感性的影响。
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Relation of 5-hydroxytryptamine and catecholamine depletion to the central depressive action of a reserpine derivative with differential action on brain monoamines.5-羟色胺和儿茶酚胺耗竭与一种对脑单胺有不同作用的利血平衍生物的中枢抑制作用的关系。
Adv Pharmacol (1962). 1968;6(Pt B):73-4. doi: 10.1016/s1054-3589(08)60297-5.

本文引用的文献

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Obesity in albino mice due to single injections of goldthioglucose.单次注射金硫葡萄糖导致白化小鼠肥胖。
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Effect of goldthioglucose injections on survival, organ damage and obesity in the rat.硫代葡萄糖金注射液对大鼠存活、器官损伤及肥胖的影响。
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On histological changes of hypothalamus in mice caused by administration of goldthioglucose.硫代葡萄糖金给药所致小鼠下丘脑的组织学变化
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Hypothalamic lesions associated with goldthioglucose-induced obesity.与金硫葡萄糖诱导的肥胖相关的下丘脑病变
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Hypothalamic lesions in goldthioglucose injected mice.注射金硫葡萄糖的小鼠下丘脑病变
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Goldthioglucose-induced lesions and quantitative changes of monoamines in the rat brain.金硫葡萄糖诱导的大鼠脑内损伤及单胺类物质的定量变化
Yonago Acta Med. 1974 Jun;18(1):1-8.
10
Stereotaxic mapping of the monoamine pathways in the rat brain.大鼠脑中单胺能通路的立体定位图谱
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