Eulderink F, Meijers K A
J Pathol. 1976 Oct;120(2):91-108. doi: 10.1002/path.1711200205.
Cervical spines (with occiputs) of 44 patients with rheumatoid arthritis (RA) were compared with 44 control spines from patients without RA, matched for sex and age. There were six severe and seven slight atlanto-axial dislocations (both horizontal and vertical, two of which had been treated surgically) in the RA group and none in the control group. Ankylosis, synchondrosis, syndesmosis, bone erosions, and redness of synovial tissue in the atlanto-axial, atlanto-occipital and cervical intervertebral joints were more frequent in the RA group than in the control spines. The lesions permitting the best discrimination between the RA and control groups were used to calculate an overall score for the whole cervical spine. Sixteen of the 44 RA patients scored higher than the highest control value; only nine scored lower than the median control score. A higher score than the average value found for the RA spines was obtained by the male patients, the patients with seropositivity or subcutaneous nodules, the patients treated with corticosteroids, the patients who died in the Department of Rheumatology, and those whose death was related to the RA itself or to the treatment given.
将44例类风湿性关节炎（RA）患者的颈椎（包括枕骨）与44例无RA患者的对照颈椎进行比较，两组在性别和年龄上相匹配。RA组有6例严重和7例轻度寰枢椎脱位（包括水平和垂直脱位，其中2例已接受手术治疗），而对照组无脱位情况。RA组寰枢椎、寰枕关节和颈椎椎间关节的关节强硬、软骨结合、韧带联合、骨质侵蚀及滑膜组织发红比对照颈椎更常见。用能最佳区分RA组和对照组的病变来计算整个颈椎的总分。44例RA患者中有16例得分高于对照的最高值；只有9例得分低于对照的中位数。男性患者、血清阳性或有皮下结节的患者、接受皮质类固醇治疗的患者、在风湿病科死亡的患者以及死亡与RA本身或所接受治疗相关的患者，其得分高于RA颈椎的平均值。
