Geschwind D H, FitzPatrick M, Mischel P S, Cummings J L
Department of Neurology, UCLA School of Medicine 90024.
Neurology. 1995 Mar;45(3 Pt 1):557-60. doi: 10.1212/wnl.45.3.557.
We report the first case of pathologic findings from brain biopsy in a patient with Sneddon's syndrome. The observations suggest that Sneddon's syndrome is not a vasculitis but is more comparable to the autoimmune vasculopathies such as the antiphospholipid antibody syndrome. Vascular thrombosis and emboli from cardiac sources are the likely causes of stroke in most cases. The success of warfarin in the treatment of antiphospholipid syndromes and the failure of immunosuppression and aspirin in the treatment of Sneddon's syndrome argue that warfarin anticoagulation may be the most appropriate intervention currently available.
我们报告了首例患有斯奈登综合征患者的脑活检病理结果。观察结果表明，斯奈登综合征并非血管炎，而更类似于自身免疫性血管病变，如抗磷脂抗体综合征。在大多数情况下，血管血栓形成和心脏来源的栓子是中风的可能原因。华法林治疗抗磷脂综合征取得成功，而免疫抑制和阿司匹林治疗斯奈登综合征失败，这表明华法林抗凝可能是目前最合适的干预措施。
