Rothenberger A, Johannsen H S, Schulze H, Amorosa H, Rommel D
University of Göttingen, Germany.
Percept Mot Skills. 1994 Dec;79(3 Pt 1):1163-70.
Reported here is the therapeutic efficacy of Tiapride with 10 10- to 17-yr.-old patients afflicted with severe stuttering problems. During the 20-wk. open, controlled study (baseline, low dose of Tiapride, high dose of Tiapride, follow-up observation without medication) the stuttering in various speech situations decreased markedly. No substantial change in different parameters of acoustic analysis and psychopathological characteristics accompanied the reduction in stuttering when group data were compared although positive effects concerning these variables could be seen in some cases. Several conclusions based on these results are presented. One assumed effect of the medication is improvement of central nervous regulatory mechanisms of speech motor coordination. Further, the value of the medication Tiapride in comprehensive stuttering therapy is discussed.
本文报告了舒必利对10名10至17岁患有严重口吃问题患者的治疗效果。在为期20周的开放对照研究（基线期、低剂量舒必利、高剂量舒必利、停药后的随访观察）中，各种言语情境下的口吃现象均显著减少。尽管在某些情况下可以看到这些变量有积极影响，但比较组数据时，口吃减少的同时，声学分析的不同参数和精神病理学特征并无实质性变化。基于这些结果得出了几个结论。药物的一个假定作用是改善言语运动协调的中枢神经调节机制。此外，还讨论了舒必利在综合口吃治疗中的价值。
