Chien M, Punwani I, Watanabe K
Department of Pediatric Dentistry, University of Illinois at Chicago, USA.
Pediatr Dent. 1995 Jan-Feb;17(1):62-4.
Larsen's syndrome is a genetic disorder of connective tissue characterized by multiple large-joint dislocations, abnormalities of hands and feet, and anomalous facial features. Although findings involving multiple systems have been added to its clinical and pathological entity, oral pathology besides cleft palate has not been reported. We report here advanced periodontitis with severe gingival inflammation in a 29-year-old Larsen's syndrome patient. Bacterial culture of subgingival plaque identified the periodontal pathogens that were present in numbers above the normal range. We speculate that the underlying defect in connective tissue may predispose Larsen's syndrome patients to periodontal destruction provoked by microbiological factors.
拉森综合征是一种结缔组织的遗传性疾病，其特征为多个大关节脱位、手足异常以及面部特征异常。尽管其临床和病理实体已增加了涉及多个系统的表现，但除腭裂外，口腔病理学方面尚未见报道。我们在此报告一名29岁拉森综合征患者出现的重度牙周炎伴严重牙龈炎症。龈下菌斑细菌培养确定了数量高于正常范围的牙周病原体。我们推测结缔组织的潜在缺陷可能使拉森综合征患者易患由微生物因素引发的牙周破坏。
