Gabbiani G
Department of Pathology, University of Geneva, Centre Médical Universitaire, Switzerland.
Pathol Res Pract. 1994 Oct;190(9-10):851-3. doi: 10.1016/S0344-0338(11)80988-X.
Fibroblast heterogeneity within normal tissues and the subsequent modulation in pathological settings are reflected by ultrastructural criteria and expression patterns of cytoskeletal proteins. The temporal or permanent expression of alpha-smooth muscle (sm) actin in fibroblastic cells is generally related to the development of structural features typical of myofibroblasts. There is evidence of site specific subtypes of myofibroblasts and even of a histogenetic diversity. While granulation tissues myofibroblasts are derived from local fibroblasts, other cell types may also have the potential to acquire a myofibroblastic phenotype. Myofibroblast phenotype can be modulated by several agents such as cytokines (e.g. GM-CSF and gamma-interferon) and extracellular matrix components.
正常组织内的成纤维细胞异质性以及病理情况下的后续调节，可通过超微结构标准和细胞骨架蛋白的表达模式来反映。成纤维细胞中α-平滑肌（sm）肌动蛋白的暂时或永久表达通常与肌成纤维细胞典型结构特征的发展有关。有证据表明存在肌成纤维细胞的位点特异性亚型，甚至存在组织发生学上的多样性。虽然肉芽组织中的肌成纤维细胞源自局部成纤维细胞，但其他细胞类型也可能有获得肌成纤维细胞表型的潜力。肌成纤维细胞表型可被多种因子调节，如细胞因子（如粒细胞-巨噬细胞集落刺激因子和γ-干扰素）和细胞外基质成分。
