Lortat-Jacob H, Esterre P, Grimaud J A
Unité de Physiopathologie Cellulaire et Moléculaire des Fibroses Tissulaires-CNRS URA 1459, Institut Pasteur de Lyon, France.
Pathol Res Pract. 1994 Oct;190(9-10):920-2. doi: 10.1016/S0344-0338(11)80996-9.
Interferon-gamma is a T cell secreted cytokine. It has a great number of biological activities, among which is the down regulation of collagen molecules. IFN-gamma acts through cell surface receptors, but also binds to heparan sulfate proteoglycans. In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.
干扰素-γ是一种由T细胞分泌的细胞因子。它具有大量的生物学活性，其中包括对胶原蛋白分子的下调作用。干扰素-γ通过细胞表面受体发挥作用，但也能与硫酸乙酰肝素蛋白聚糖结合。在体内，推测硫酸乙酰肝素/干扰素-γ的相互作用可调节细胞因子的活性和可用性。
