Zel'tser M E, Chuvakova T K, Mezinova N N, Bazarbekova R B, Kobzar' N N, Nurbekova A A, Akyshbaev A A, Kurmanova A K, Zhubanysheva K B, Kim G G
Probl Endokrinol (Mosk). 1994 Sep-Oct;40(5):18-20.
Relationships between chronic iodine deficiency and, among other things, endemic goiter in women and adaptation of their babies in the early neonatal period were studied. A total of 125 women with endemic goiter of the Ist-IInd degrees and their newborns were examined. The diagnosis of endemic goiter was verified by the findings of an objective examination, ultrasonic examination, and puncture biopsy of the thyroid. Blood levels of triiodothyronine and thyroxin were measured in the women on days 3-4 postpartum. In the newborns Apgar score, body mass and length at birth, degree of maturity, physiologic body mass loss, duration of the icteric syndrome, time of umbilical cord drop off, and immunity status from the data of NBT test were assessed. Forty-five women without goiter and their newborns were controls. Postpartum measurements of triiodothyronine and thyroxin levels in the blood of patients with endemic goiter brought the authors to a conclusion that subclinical hypothyrosis was characteristic of them. Adaptation processes in the early neonatal period were found disordered in the newborns of mothers with endemic goiter. This manifested by a higher, vs. controls, incidence of asphyxia, hypotrophy, signs of the CNS involvement, and respiratory distress syndrome. Initial body mass recovery, disappearance of the icteric syndrome, umbilical cord loss were delayed in these newborns in comparison with the controls, and statistically reliable deviations in their immune status were revealed.
研究了慢性碘缺乏与女性地方性甲状腺肿以及她们的婴儿在新生儿早期的适应性之间的关系。总共检查了125名患有I-II度地方性甲状腺肿的女性及其新生儿。通过客观检查、超声检查和甲状腺穿刺活检结果验证了地方性甲状腺肿的诊断。在产后第3-4天测量了这些女性血液中的三碘甲状腺原氨酸和甲状腺素水平。评估了新生儿的阿氏评分、出生时的体重和身长、成熟度、生理性体重减轻、黄疸综合征持续时间、脐带脱落时间以及根据硝基蓝四氮唑试验数据得出的免疫状态。45名无甲状腺肿的女性及其新生儿作为对照。对患有地方性甲状腺肿患者血液中三碘甲状腺原氨酸和甲状腺素水平的产后测量使作者得出结论，亚临床甲状腺功能减退是其特征。发现患有地方性甲状腺肿母亲的新生儿在新生儿早期的适应过程紊乱。这表现为与对照组相比，窒息、发育不良、中枢神经系统受累体征和呼吸窘迫综合征的发生率更高。与对照组相比，这些新生儿的初始体重恢复、黄疸综合征消失、脐带脱落延迟，并且其免疫状态存在统计学上可靠的偏差。
