玻璃体切割联合柔红霉素及硅油注入术后视网膜前增殖的组织病理学研究
Histopathologic study of epiretinal proliferations after vitrectomy with daunomycin and silicone oil.
作者信息
Mietz H, Walshe R, Wiedemann P, Heimann K, Green W R
机构信息
Department of Ophthalmology, University of Cologne, Germany.
出版信息
Retina. 1994;14(5):425-9. doi: 10.1097/00006982-199414050-00006.
PURPOSE
The cellular composition of primary and recurrent periretinal proliferations has been widely described. The use of daunomycin, an antiproliferative antibiotic, has been recommended to reduce these proliferations. Two recurrent membranes after intraoperative application of daunomycin were examined.
METHODS
Two epiretinal membranes, which were removed 5 months and 20 months after vitrectomy with daunomycin, were examined by light and electron microscopy to determine the structure and cellular composition of these membranes.
RESULTS
The matrix of the membranes consisted of new collagen with fiber diameters between 20 and 22 nm. Fibrocytes and macrophages were present in both specimens. Retinal pigment epithelial cells and fibrous astrocytes were present in only one specimen.
CONCLUSION
Retinal pigment epithelial cells, which are consistently present in primary periretinal membranes, were found in only one of the two specimens examined. Myofibroblasts, also normally present, were not found. The other cells found are typically seen in primary periretinal proliferations.
目的
原发性和复发性视网膜周增殖的细胞组成已被广泛描述。有人推荐使用抗增殖抗生素柔红霉素来减少这些增殖。对术中应用柔红霉素后的两片复发性膜进行了检查。
方法
通过光镜和电镜检查两片视网膜前膜，这两片膜是在玻璃体切除联合柔红霉素治疗后5个月和20个月取出的，以确定这些膜的结构和细胞组成。
结果
膜的基质由纤维直径在20至22纳米之间的新胶原组成。两个标本中均存在纤维细胞和巨噬细胞。仅在一个标本中存在视网膜色素上皮细胞和纤维性星形胶质细胞。
结论
在原发性视网膜周膜中始终存在的视网膜色素上皮细胞，在所检查的两个标本中仅在其中一个中发现。同样通常存在的肌成纤维细胞未被发现。所发现的其他细胞通常见于原发性视网膜周增殖。
Zotero 插件