Frugière A, Barillot J C
Département de Physiologie et Neurophysiologie, UA CNRS 1832, Faculté des Sciences et Techniques Saint-Jéróme, Marseille, France.
Respir Physiol. 1994 Nov-Dec;98(3):295-304. doi: 10.1016/0034-5687(94)90078-7.
In anesthetized (n = 26) or decerebrate (n = 15) rats, vagotomized, paralyzed and artificially ventilated, we recorded efferent respiratory-related discharges of nerves supplying the pharyngeal muscles, i.e. the glossopharyngeal nerve (IX; n = 30) and the pharyngeal ramus of the vagus nerve (PH.X; n = 33). In both types of preparation, all IX nerves fired during inspiration (I); most PH.X fired either during I (n = 11), expiration (E, n = 12), or both phases (n = 4); some of them were continuously active, without any respiratory modulation (n = 6). We also examined the timing of inspiratory pharyngeal bursts in relation to the phrenic (inspiratory) bursts. We found that the burst onset occurred significantly earlier in pharyngeal nerves than in phrenic ones (pharyngeal-to-phrenic delay). In anesthetized animals, this pharyngeal-to-phrenic delay was long enough to reveal that inspiratory activity appeared first on IX, then on PH.X, and then on phrenic nerves. Since hypoxia did not significantly alter the pharyngeal-to-phrenic delay, we conclude that a reliable organization of the inspiratory drive on pharyngeal and diaphragmatic muscles should exist, in the rat.
在麻醉（n = 26）或去大脑（n = 15）的大鼠中，切断迷走神经、使其麻痹并进行人工通气，我们记录了支配咽肌的神经的传出性呼吸相关放电，即舌咽神经（IX；n = 30）和迷走神经的咽支（PH.X；n = 33）。在两种制备类型中，所有IX神经在吸气（I）时放电；大多数PH.X神经在吸气（n = 11）、呼气（E，n = 12）或两个阶段（n = 4）放电；其中一些持续活跃，无任何呼吸调制（n = 6）。我们还研究了吸气性咽爆发相对于膈神经（吸气）爆发的时间。我们发现咽神经的爆发起始明显早于膈神经（咽 - 膈延迟）。在麻醉动物中，这种咽 - 膈延迟足够长，以至于可以发现吸气活动首先出现在IX神经，然后出现在PH.X神经，最后出现在膈神经。由于缺氧并未显著改变咽 - 膈延迟，我们得出结论，在大鼠中，应该存在对咽肌和膈肌吸气驱动的可靠组织。
