Nagai H
Drug Safety Research Laboratories, Takada Chemical Industries, Ltd., Osaka, Japan.
Toxicol Pathol. 1994 Sep-Oct;22(5):555-8. doi: 10.1177/019262339402200511.
Spontaneous goblet cell metaplasia in the pulmonary alveolar epithelium in a 110-wk-old male Jcl:Wistar rat is described. The rat had a dark red spherical mass in the center of the left lobe of the lung. The mass consisted of distended alveoli and bronchioles filled with mucus and nonciliated epithelial cells with numerous goblet cells lining the alveoli on the periphery of the mass. The goblet cells produced Alcian blue- and high iron diamine-positive sulfated glycoprotein differing from the sialylated glycoprotein seen in the normal rat airway surface epithelium. To the best of this investigator's knowledge, this is the first report dealing with detailed morphological and histochemical features of goblet cell metaplasia in the pulmonary alveolar epithelium resulting in mass formation due to mucous production.
描述了一只110周龄雄性Jcl:Wistar大鼠肺泡上皮中自发的杯状细胞化生。该大鼠左肺叶中央有一个暗红色球形肿块。肿块由扩张的肺泡和细支气管组成，充满黏液和非纤毛上皮细胞，肿块周边的肺泡内衬有大量杯状细胞。杯状细胞产生阿尔辛蓝和高铁二胺阳性的硫酸化糖蛋白，不同于正常大鼠气道表面上皮中所见的唾液酸化糖蛋白。据该研究者所知，这是第一份关于肺泡上皮杯状细胞化生导致黏液产生形成肿块的详细形态学和组织化学特征的报告。
