Paleev N R, Il'chenko V A, Golikov P P, Stotskaia T V, Karandashov V I, Kol'tsun S S, Tishenina R S, Iurina T M, Massarygin V V, Stadnikov L A
Ter Arkh. 1994;66(12):56-9.
The paper reports glucocorticoid actions in bronchial asthma, covers problems of individual sensitivity to glucocorticoids and resistance to hormones, illustrates the dependence of beclometasone dipropionate efficacy on condition of glucocorticoid receptors in alveolar macrophages and clinical appearance of the disease, describes physiological features of patients with hormone-resistant bronchial asthma and its new treatment (extracorporeal photohemotherapy) allowing reduction of prednisolone dose in 14 of 15 patients from 29.6 to 11.4 mg/day, on the average.
该论文报道了糖皮质激素在支气管哮喘中的作用,涵盖了个体对糖皮质激素的敏感性和激素抵抗问题,阐述了二丙酸倍氯米松疗效与肺泡巨噬细胞中糖皮质激素受体状况及疾病临床表现的相关性,描述了激素抵抗性支气管哮喘患者的生理特征及其新的治疗方法(体外光化学疗法),该疗法使15例患者中的14例泼尼松龙剂量平均从29.6毫克/天降至11.4毫克/天。