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[荷兰绵羊线虫的抗蠕虫药耐药性]

[Anthelmintic resistance in sheep nematodes in The Netherlands].

作者信息

Borgsteede F H, Pekelder J J, Dercksen D P, Sol J, Vellema P, Gaasenbeek C P, van der Linden J N

机构信息

DLO-Instituut voor Veehouderij en Diergezondheid (ID-DLO), Lelystad.

出版信息

Tijdschr Diergeneeskd. 1995 Mar 15;120(6):173-6.

PMID:7900149
Abstract

The prevalence of anthelmintic resistant nematodes in sheep was investigated in 1994 with a faecal egg count reduction test (FECRT) and an egg hatch assay (EHA) on 71 farms in the Netherlands. A benzimidazole (oxfendazole) was tested on 70 farms, ivermectin on 51 farms, and levamisole on 35 farms. Based on the FECRT benzimidazole resistance was present on 56 farms, 2 were suspected, on 9 no resistance was observed, while 3 farms could not be tested due to a too low egg output before treatment. No clear indications for resistance to ivermectin and levamisole were found. Benzimidazole resistance was demonstrated in Haemonchus contortus, Cooperia curticei, Ostertagia spp. and/or Trichostrongylus spp. No resistance was seen in species from the genus Nematodirus, Chabertia ovina and/or Oesophagostomum spp. De results of the EHA confirmed the results of the FECRT. On 59 farms the ED50 value was > 0.12 microgram ml-1 thiabendazole.

摘要

1994年,通过粪便虫卵计数减少试验(FECRT)和虫卵孵化试验(EHA),对荷兰71个农场绵羊体内抗驱虫药线虫的流行情况进行了调查。在70个农场测试了苯并咪唑(奥芬达唑),在51个农场测试了伊维菌素,在35个农场测试了左旋咪唑。根据FECRT,56个农场存在苯并咪唑抗性,2个农场疑似有抗性,9个农场未观察到抗性,而3个农场由于治疗前虫卵产量过低无法进行测试。未发现对伊维菌素和左旋咪唑有抗性的明确迹象。在捻转血矛线虫、柯氏古柏线虫、奥斯特他属线虫和/或毛圆线虫属线虫中证实存在苯并咪唑抗性。在细颈线虫属、绵羊夏伯特线虫和/或食道口线虫属的物种中未观察到抗性。EHA的结果证实了FECRT的结果。在59个农场,噻苯达唑的ED50值>0.12微克/毫升。

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