Zetka M, Rose A
Institute of Zoology, University of Fribourg, Pérolles, Switzerland.
Trends Genet. 1995 Jan;11(1):27-31. doi: 10.1016/s0168-9525(00)88983-0.
The many features that have made the hermaphroditic nematode Caenorhabditis elegans a good model system for studying development have also attracted investigators to the study of meiosis. Genetic analysis suggests that in C. elegans there are two types of chromosomal sites required for proper meiotic function. The first is needed early in meiosis for recombination and segregation. The second is involved in the mechanisms that establish the normal frequency and distribution of exchange. Genes whose products may interact with these sites have been identified by mutant analysis. Study of these mutations in the nematode is enhancing our general understanding of meiotic functions.
雌雄同体的线虫秀丽隐杆线虫所具有的诸多特性使其成为研究发育的良好模式系统，这也吸引了研究人员对减数分裂进行研究。遗传分析表明，在秀丽隐杆线虫中，正常减数分裂功能需要两类染色体位点。第一类位点在减数分裂早期用于重组和分离。第二类位点参与建立交换的正常频率和分布的机制。通过突变分析已鉴定出其产物可能与这些位点相互作用的基因。对线虫中这些突变的研究正在加深我们对减数分裂功能的总体理解。
