Venugopal S, Shah D J, Duncan N D, Carpenter R
Department of Surgery, U.W.I., Jamaica.
West Indian Med J. 1994 Dec;43(4):134-7.
Of the twenty-nine children with solid renal tumours treated at the University Hospital of the West Indies (UHWI) between January, 1972 and December, 1991, there were twenty-eight cases of nephroblastoma and one of mesoblastic nephroma. Peak incidence was between the ages of two and four years. Twenty-five children had radical nephrectomy while one had bilateral partial nephrectomy. In thirteen cases, pre-operative chemotherapy +/- radiotherapy was used. Post-operative chemotherapy and radiotherapy were used in 24 and 13 cases, respectively. Stage of the tumour was the most decisive factor influencing the outcome. Whereas there was a 100% cure rate in Stages I and II, Stage III had only a 55.5% survival rate and none of the Stage IV survived. Bilateral (Stage V) tumours are curable if individual tumours are localised, as in one of the two cases. The benign mesoblastic nephroma, in a one-month-old infant, was cured by nephrectomy alone. While the present therapy of radical nephrectomy along with combination chemotherapy is satisfactory for early stages, more aggressive adjuvant therapy is needed for improving the results in Stages III and IV.
1972年1月至1991年12月期间，在西印度群岛大学医院（UHWI）接受治疗的29例实体肾肿瘤患儿中，有28例肾母细胞瘤和1例中胚层肾瘤。发病高峰年龄在2至4岁之间。25名儿童接受了根治性肾切除术，1名接受了双侧部分肾切除术。13例采用术前化疗±放疗。术后化疗和放疗分别应用于24例和13例。肿瘤分期是影响预后的最决定性因素。I期和II期的治愈率为100%，III期的生存率仅为55.5%，IV期无一例存活。双侧（V期）肿瘤如果单个肿瘤局限，如两例中的一例，则可治愈。1例1个月大婴儿的良性中胚层肾瘤仅通过肾切除术治愈。虽然目前根治性肾切除术联合化疗的治疗方法对早期病例是令人满意的，但对于改善III期和IV期的治疗效果，需要更积极的辅助治疗。
