Kukuev L A, Sergutina A V, Gershteĭn L M
Zh Nevrol Psikhiatr Im S S Korsakova. 1994;94(5):28-32.
In the course of a long-term L-DOPA administration (14 days) and 2 weeks after its cessation the activities of some protein enzymes (aminopeptidase, acid phosphatase), neuromediator (MAO, ACE) and oxidative (glutamate dehydrogenase, glucose-6-phosphate dehydrogenase) metabolism were studied by quantitative cytochemical methods in brain motor structures (sensorimotor cortex, caudate nucleus) and in structures not directly related to motor functions (hippocampus) of rats with high and low motor activity. After L-DOPA (madapar) cessation significant changes were revealed in the formation of motor system of the brain, primarily in the group of rats with low motor activity. It is suggested that a decrease in MAO activity after madapar cessation may be responsible for dyskinesia arising after cessation of L-DOPA preparations treatment.
在长期给予左旋多巴（14天）及停药2周后，采用定量细胞化学方法，对高运动活性和低运动活性大鼠脑运动结构（感觉运动皮层、尾状核）及与运动功能无直接关联的结构（海马体）中某些蛋白质酶（氨肽酶、酸性磷酸酶）、神经介质（单胺氧化酶、血管紧张素转换酶）以及氧化代谢（谷氨酸脱氢酶、葡萄糖-6-磷酸脱氢酶）的活性进行了研究。左旋多巴（美多巴）停药后，大脑运动系统的形成出现了显著变化，主要发生在低运动活性的大鼠组中。有人认为，美多巴停药后单胺氧化酶活性降低可能是左旋多巴制剂治疗停药后出现运动障碍的原因。
