Ulfvarson U, Dahlqvist M, Sandström T, Bergström B, Ekholm U, Lagerstrand L, Figler B, Nilsen A, Bjermer L, Trønnes T
Department of Environmental Technology and Work Science, Royal Institute of Technology, Stockholm, Sweden.
Am J Ind Med. 1995 Jan;27(1):91-106. doi: 10.1002/ajim.4700270109.
The airway resistance, compliance of the respiratory system, transfer factor, and alveolar volume of 33 healthy rabbits were studied before and after exposure to diluted diesel exhaust generated in an experimental motor. Three diesel fuels and two particle traps were tested. Subsequent to the post-exposure lung function measurements, the animals were sacrificed and the lungs were processed for morphologic examination. The concentrations of particles, nitrogen dioxide, and formaldehyde were measured. The inflammatory airway changes were most pronounced in animals exposed to exhaust from standard fuel. Small changes were identified in animals exposed to exhaust filtered through the catalytic trap as well or exposed to unfiltered exhaust from fuels intended for densely built-up areas. Increase in compliance of the respiratory system was associated with the concentration of soot particles and formaldehyde. Compliance decreased significantly in animals exposed to exhaust from standard fuel filtered through the particle traps and increased almost significantly in animals exposed to unfiltered exhaust from the same fuel.
对33只健康兔子在暴露于实验发动机产生的稀释柴油机废气前后的气道阻力、呼吸系统顺应性、转移因子和肺泡容积进行了研究。测试了三种柴油燃料和两种颗粒捕集器。在暴露后进行肺功能测量后，处死动物并对肺进行形态学检查。测量了颗粒物、二氧化氮和甲醛的浓度。暴露于标准燃料废气中的动物气道炎症变化最为明显。暴露于通过催化捕集器过滤的废气中的动物以及暴露于适用于密集建成区的燃料的未过滤废气中的动物也发现了微小变化。呼吸系统顺应性的增加与烟尘颗粒和甲醛的浓度有关。暴露于通过颗粒捕集器过滤的标准燃料废气中的动物顺应性显著降低，而暴露于相同燃料的未过滤废气中的动物顺应性几乎显著增加。
