Shults C W, Kimber T A
Neurology Service, VA Medical Center, San Diego, CA 92161.
Brain Res Dev Brain Res. 1993 Sep 17;75(1):136-40. doi: 10.1016/0165-3806(93)90073-j.
At P0, P2 and P3, islands of increased density of Thy-1-immunoreactive (Thy-1-IR) material, which coincided with the islands of dense dopaminergic axons, were noted in the striatum. By P5, the distribution of Thy-1-IR material was homogeneous throughout the developing striatum, but islands of dense dopaminergic axons persisted. The pattern of appearance of Thy-1, which is involved in extension of neurites and stabilization of synapses, suggests that it is involved in formation of connections between the substantia nigra and striatum in the developing rat brain.
在出生后第0天、第2天和第3天，在纹状体中发现了Thy-1免疫反应性（Thy-1-IR）物质密度增加的区域，这些区域与密集的多巴胺能轴突区域相重合。到出生后第5天，Thy-1-IR物质在整个发育中的纹状体中分布均匀，但密集的多巴胺能轴突区域仍然存在。Thy-1参与神经突的延伸和突触的稳定，其出现模式表明它参与了发育中大鼠脑黑质与纹状体之间连接的形成。
