对神经母细胞瘤患者尿液样本中单胺类物质及其代谢产物的同步分析。

Simultaneous analyses of monoamines and their metabolites in urine specimens of patients with neuroblastoma.

Takeda N

Department of Biotechnology, Research and Development Center, COSMO Research Institute, Satte, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jul;105(3):373-7. doi: 10.1016/0742-8413(93)90073-t.

Abstract

Tyrosine and tryptophan, as well as 26 metabolites of these amino acids, were analyzed simultaneously in urine specimens from patients with neuroblastoma and control infants by a three-dimensional HPLC system to develop an early diagnosis. 2. Levels of detected compounds in urine from patients with neuroblastoma were generally higher in the case of catecholamines and lower in the case of indolalkylamines than those in controls. 3. The pathways of Dopamine-3,4-Dihydroxyphenylacetic acid-Vanillylmandelic acid, Dopamine-3-Methoxy-4-hydroxyphenylethylene glycol-Vanillylmandelic acid and Tyrosine-4-Hydroxyphenylacetic acid-4 were, in particular, found to be active in patients with neuroblastoma.

摘要

采用三维高效液相色谱系统同时分析神经母细胞瘤患者和对照婴儿尿液样本中的酪氨酸、色氨酸以及这两种氨基酸的26种代谢产物，以进行早期诊断。2. 神经母细胞瘤患者尿液中检测到的化合物，儿茶酚胺类通常高于对照组，而吲哚烷基胺类则低于对照组。3. 尤其发现，多巴胺 - 3,4 - 二羟基苯乙酸 - 香草扁桃酸、多巴胺 - 3 - 甲氧基 - 4 - 羟基苯乙二醇 - 香草扁桃酸和酪氨酸 - 4 - 羟基苯乙酸 - 4的代谢途径在神经母细胞瘤患者中较为活跃。