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[Establishment of the multidrug-resistant cell line K562/A02 and its drug-resistant properties].

作者信息

Luan F J

机构信息

Institute of Hematology, CAMS, Tianjin.

出版信息

Zhonghua Zhong Liu Za Zhi. 1993 Mar;15(2):101-3.

PMID:7900978
Abstract

A multidrug-resistant cell line K562/A02 was obtained from its parent K562 by long-term adriamycin (ADM) induction and cloning selection. The K562/A02 has high expression of mdr-1 P-glycoprotein (P170), strong resistance to its induction drug ADM and some other anticancer drugs such as daunorubicin, VP16, homoharringtonine and amsacrine. Its intracellular concentration of daunorubicin is much lower than that in its parent K562, which can be partially reversed by cyclosporin-A and verapamil.

摘要

相似文献

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The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells.
姜黄素的短期治疗能显著降低细胞活力，诱导细胞凋亡，而铜离子能增强多药耐药的 K562/A02 细胞的这些作用。
Mol Cell Biochem. 2012 Jan;360(1-2):253-60. doi: 10.1007/s11010-011-1064-2. Epub 2011 Sep 22.