Ezenwaka E C, Akanji A O, Adejuwon C A, Abbiyesuku F M, Akinlade K S
Department of Chemical Pathology, University College Hospital, Ibadan, Nigeria.
Int J Gynaecol Obstet. 1993 Aug;42(2):155-9. doi: 10.1016/0020-7292(93)90630-f.
The aim of the study was to investigate changes in insulin sensitivity during the menstrual cycle, in a group of regularly menstruating black African women.
Insulin responses to intravenous glucose (300 mg/kg) were assessed, for up to 3 h, in 3 groups of age- and body mass-matched non-obese sedentary Nigerian women: Group A, 7 women in the menstrual follicular phase; Group B, 7 women in the menstrual luteal phase; C, 7 men.
Women in the menstrual luteal phase had the greatest integrated first-phase insulin response and insulin/glucose ratios, much higher than the similar values for these variables obtained in other groups. This suggests that the menstrual luteal phase is associated with relative insulin resistance.
Black African women in the menstrual luteal phase demonstrate an exaggerated insulin response to an acute glucose load and are thus relatively insulin-insensitive. This confirms previous observations in Caucasians.
本研究旨在调查一组月经周期规律的非洲黑人女性在月经周期中胰岛素敏感性的变化。
对3组年龄和体重匹配的非肥胖久坐尼日利亚女性进行长达3小时的静脉注射葡萄糖（300mg/kg）后的胰岛素反应评估：A组，7名处于月经卵泡期的女性；B组，7名处于月经黄体期的女性；C组，7名男性。
处于月经黄体期的女性具有最大的整合早期胰岛素反应和胰岛素/葡萄糖比值，远高于其他组这些变量的相似值。这表明月经黄体期与相对胰岛素抵抗有关。
处于月经黄体期的非洲黑人女性对急性葡萄糖负荷表现出过度的胰岛素反应，因此相对胰岛素不敏感。这证实了先前在白种人中的观察结果。
