Management of gestational trophoblastic disease. ACOG Technical Bulletin Number 178-March 1993.

Despite the potentially serious outcome of malignant GTD, most women with all forms of GTD can be successfully diagnosed and treated, with preservation of their normal reproductive function. It is important to manage hydatidiform mole properly in order to minimize acute complications, identify malignant sequelae promptly, and begin therapy. It is important to individualize therapy for women with malignant GTD based upon known risk factors, using less toxic therapy for patients with low-risk disease and aggressive multiagent therapy for patients with high-risk disease.