自发性高血压大鼠比目鱼肌的改变不依赖于β2 - 肾上腺素能受体的激活。
Soleus muscle alterations in spontaneously hypertensive rats are not dependent on activation of beta 2-adrenergic receptors.
作者信息
Benbachir-Lamrini L, Koubi H, Sempore B, Mayet M H, Frutoso J, Cottet-Emard J M, Favier R J
机构信息
Unité de Recherches Associée 1341 Centre National de la Recherche Scientifique, Université Claude Bernard, Lyon, France.
出版信息
J Auton Nerv Syst. 1993 Aug-Sep;44(2-3):161-70. doi: 10.1016/0165-1838(93)90028-s.
The effects of selective beta 2-adrenergic blockade with ICI 118,551 on the histochemical, biochemical, and contractile properties of slow-twitch soleus muscle from spontaneously hypertensive (SHR) and normotensive (WKY) rats were examined from birth to 8-10 weeks of age. Chronic treatment of normotensive rats with ICI 118,551 caused an impairment in the differentiation of slow type fibers during development but failed to alter the fiber type distribution of hypertensive rats. beta 2-Adrenoreceptor blockade was ineffective in reducing the enhanced glycolytic and oxidative capacities of soleus in hypertensive rats. The suggestion can be made that beta 2-adrenoreceptor activation is not responsible, at least directly, for the histochemical and biochemical alterations of slow muscle from hypertensive rats.
研究了从出生到8至10周龄时，用ICI 118,551进行选择性β2-肾上腺素能阻断对自发性高血压（SHR）大鼠和正常血压（WKY）大鼠慢肌比目鱼肌的组织化学、生化及收缩特性的影响。用ICI 118,551对正常血压大鼠进行慢性治疗会导致发育过程中慢肌纤维分化受损，但未能改变高血压大鼠的纤维类型分布。β2-肾上腺素能受体阻断对降低高血压大鼠比目鱼肌增强的糖酵解和氧化能力无效。可以认为，β2-肾上腺素能受体激活至少不是直接导致高血压大鼠慢肌组织化学和生化改变的原因。
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