Namiki T, Egawa M, Tominaga S, Inoue S, Takamura Y
Third Department of Internal Medicine, Yokohama City University, Medical School, Japan.
J Auton Nerv Syst. 1993 Aug-Sep;44(2-3):217-23. doi: 10.1016/0165-1838(93)90034-r.
The effects of administration of an inhibitory GABAergic or excitatory glutaminergic neurotransmitter into the lateral hypothalamic area (LHA) on gastric acids, an aggressive mechanism, and transepithelial potential difference (PD) and mucosal blood flow (MBF), defensive mechanisms, were examined in anesthetized rats, since lesions of LHA in these animals cause gastric mucosal damage and electrical stimulation stimulates gastric acids and antral contractions. Microinfusion of the inhibitory neurotransmitter, muscimol (GABA agonist) resulted in an increase in gastric acid secretion and in PD and MBF. The GABA antagonists picrotoxin and bicuculline methiodide, in contrast, decreased these three factors. The excitatory neurotransmitter L-glutamate induced only an increase of MBF. Thus, the GABAergic system in LHA stimulates the gastric functions, both defensive and aggressive mechanisms, while the glutaminergic system increases only a portion of the defensive system. The results suggest that there is a significant interaction between LHA and stomach functions.
鉴于在这些动物中下丘脑外侧区（LHA）损伤会导致胃黏膜损伤，而电刺激会刺激胃酸分泌和胃窦收缩，因此研究人员在麻醉大鼠中检测了向LHA注射抑制性γ-氨基丁酸能（GABAergic）或兴奋性谷氨酸能神经递质对胃酸（一种攻击机制）、跨上皮电位差（PD）和黏膜血流量（MBF，防御机制）的影响。微量注射抑制性神经递质蝇蕈醇（GABA激动剂）会导致胃酸分泌以及PD和MBF增加。相比之下，GABA拮抗剂印防己毒素和甲碘化荷包牡丹碱会降低这三个因素。兴奋性神经递质L-谷氨酸仅引起MBF增加。因此，LHA中的GABA能系统刺激胃的功能，包括防御和攻击机制，而谷氨酸能系统仅增加部分防御系统。结果表明，LHA与胃功能之间存在显著的相互作用。
