血小板活化因子与大鼠离体胃条对前列腺素E2的反应
Platelet activating factor and the responses of rat isolated stomach strip to prostaglandin E2.
作者信息
Izzo A A, Mascolo N, Autore G, Capasso F
机构信息
Department of Experimental Pharmacology, University of Naples, Federico II, Italy.
出版信息
J Pharm Pharmacol. 1993 Aug;45(8):761-2. doi: 10.1111/j.2042-7158.1993.tb07106.x.
The effect of platelet activating factor (PAF) on contractions evoked by acetylcholine, 5-hydroxytryptamine (5-HT) and prostaglandin E2 (PGE2) was studied in-vitro on rat stomach strip. Addition of PAF to the organ bath increased PGE- but not 5-HT- or acetylcholine-evoked responses. The effect of PAF was unaffected by atropine, methysergide or indomethacin, but prevented by a specific PAF receptor antagonist BN 52021. The data support a specific interaction between PAF and PGE2 on rat stomach strip.
在体外对大鼠胃条进行研究，观察血小板活化因子（PAF）对乙酰胆碱、5-羟色胺（5-HT）和前列腺素E2（PGE2）诱发收缩的影响。向器官浴槽中添加PAF可增强PGE2诱发的反应，但不增强5-HT或乙酰胆碱诱发的反应。PAF的作用不受阿托品、麦角新碱或吲哚美辛的影响，但可被特异性PAF受体拮抗剂BN 52021阻断。这些数据支持PAF与PGE2在大鼠胃条上存在特异性相互作用。
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