不稳定型心绞痛患者的血浆脂蛋白(a)水平与纤溶活性

Plasma lipoprotein(a) levels and fibrinolytic activity in patients with unstable angina.

作者信息

Okubo H, Yasue H, Ogawa H, Misumi I, Masuda T, Miyao Y, Sakamoto T

机构信息

Division of Cardiology, Kumamoto University School of Medicine, Japan.

出版信息

Jpn Circ J. 1993 Oct;57(10):947-54. doi: 10.1253/jcj.57.947.

DOI:10.1253/jcj.57.947

PMID:7901435

Abstract

The relationship between plasma Lipoprotein(a) (Lp(a)) levels and plasminogen activator inhibitor (PAI) activity and tissue plasminogen activator (t-PA) antigen levels were studied in 15 patients with unstable angina. Plasma levels of Lp(a) (mg/dl) were significantly higher in patients with unstable angina after treatment 2 weeks than on admission (19.7 +/- 2.8 vs 14.6 +/- 2.3, p < 0.01). On the other hand, the plasma levels of PAI activity (IU/ml) and t-PA antigen (ng/ml) in patients with unstable angina were significantly higher on admission than after treatment (PAI activity: 11.4 +/- 1.4 vs 7.7 +/- 1.5, t-PA antigen: 8.7 +/- 0.9 vs 7.0 +/- 0.9, p < 0.01). We conclude that patients with unstable antigen have reduced fibrinolytic capacity, as indicated by increased PAI activity, and that the plasma Lp(a) level may be decreased due to binding with fibrin during the acute stage of unstable angina.

摘要

对15例不稳定型心绞痛患者的血浆脂蛋白(a) [Lp(a)]水平与纤溶酶原激活物抑制剂(PAI)活性及组织纤溶酶原激活物(t-PA)抗原水平之间的关系进行了研究。不稳定型心绞痛患者治疗2周后的血浆Lp(a)水平（mg/dl）显著高于入院时（19.7±2.8对14.6±2.3，p<0.01）。另一方面，不稳定型心绞痛患者入院时的血浆PAI活性（IU/ml）和t-PA抗原水平（ng/ml）显著高于治疗后（PAI活性：11.4±1.4对7.7±1.5，t-PA抗原：8.7±0.9对7.0±0.9，p<0.01）。我们得出结论，不稳定型心绞痛患者的纤溶能力降低，表现为PAI活性增加，并且在不稳定型心绞痛急性期，血浆Lp(a)水平可能因与纤维蛋白结合而降低。