Landi M, Croci T, Manara L
SANOFI-MIDY S.p.A. Research Center, Milan, Italy.
Life Sci. 1993;53(18):PL297-302. doi: 10.1016/0024-3205(93)90590-y.
We investigated the putative common nature of the rat atypical beta-adrenoceptors mediating white adipocyte lipolysis and proximal colon motility inhibition, using the non-selective antagonist alprenolol and agonist isoprenaline and the selective agonists SR 58611A and BRL 37344. Results in either isolated intestinal and fat tissues were consistent with: isoprenaline acting through both typical (beta 1, beta 2) and typical beta-adrenoceptors; SR 58611A and BRL 37344 acting solely through the latter. The identical pA2 values obtained with alprenolol, irrespective of the tissue and the selective agonist (SR 58611A or BRL 37344) used, support the high functional homology of the atypical beta-adrenoceptors in rat colon and adipocytes.
我们使用非选择性拮抗剂阿普洛尔、激动剂异丙肾上腺素以及选择性激动剂SR 58611A和BRL 37344，研究了介导白色脂肪细胞脂解作用和近端结肠运动抑制的大鼠非典型β-肾上腺素能受体的假定共同特性。在分离的肠组织和脂肪组织中的结果均表明：异丙肾上腺素通过典型的（β1、β2）和非典型β-肾上腺素能受体发挥作用；SR 58611A和BRL 37344仅通过后者发挥作用。无论使用何种组织以及选择性激动剂（SR 58611A或BRL 37344），阿普洛尔获得的相同pA2值均支持大鼠结肠和脂肪细胞中非典型β-肾上腺素能受体具有高度功能同源性。
