Hajdu K, Golbus M S
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, School of Medicine, San Francisco.
West J Med. 1993 Sep;159(3):356-9.
Modern physicians desire not only to treat but to cure congenital diseases. In a wide variety of diseases, bone marrow transplantation can be the tool of final cure. The limitations and risks of this procedure have motivated researchers to search for an earlier and safer method of treatment. Special features of fetal immune systems make it possible to perform the transplantation during fetal life using fetal hematopoietic stem cells, thus avoiding many of the side effects of bone marrow transplantation in neonatal life. We review the experimental work done with animal models in this field and the human trials that have been published recently.
现代医生不仅希望治疗先天性疾病，还希望治愈它们。在各种各样的疾病中，骨髓移植可能是最终治愈的手段。该手术的局限性和风险促使研究人员寻找更早、更安全的治疗方法。胎儿免疫系统的特殊特征使得在胎儿期使用胎儿造血干细胞进行移植成为可能，从而避免了新生儿期骨髓移植的许多副作用。我们回顾了该领域用动物模型进行的实验工作以及最近发表的人体试验。
