药物性高热

Drug-induced hyperthermia.

作者信息

Nimmo S M, Kennedy B W, Tullett W M, Blyth A S, Dougall J R

机构信息

Intensive Therapy Unit, Western Infirmary, Glasgow.

出版信息

Anaesthesia. 1993 Oct;48(10):892-5. doi: 10.1111/j.1365-2044.1993.tb07423.x.

DOI:10.1111/j.1365-2044.1993.tb07423.x

PMID:7902026

Abstract

Drugs with antidopaminergic properties and those capable of stimulating serotonin release can be responsible for hyperthermia syndromes such as neuroleptic malignant syndrome and serotonin syndrome. Dopamine and serotonin are important neurotransmitters in temperature regulation and it is likely that these reactions result from drug-induced changes in neurotransmitter levels. We describe three cases of drug-induced hyperthermia, discuss their aetiology and management, with both general measures and therapies designed to redress neurotransmitter imbalance.

摘要

具有抗多巴胺能特性的药物以及能够刺激血清素释放的药物，可能会导致诸如抗精神病药恶性综合征和血清素综合征等高热综合征。多巴胺和血清素是体温调节中的重要神经递质，这些反应很可能是由药物引起的神经递质水平变化所致。我们描述了三例药物引起的高热病例，讨论了其病因及处理方法，包括一般措施以及旨在纠正神经递质失衡的治疗方法。