Hernández J L, Palacios-Araus L, Echevarría S, Herrán A, Campo J F, Riancho J A
Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain.
Postgrad Med J. 1997 Dec;73(866):779-84. doi: 10.1136/pgmj.73.866.779.
Patients infected by the human immunodeficiency virus are predisposed to many infectious and noninfectious complications and often receive a variety of drugs. Furthermore, they seem to have a particular susceptibility to idiosyncratic adverse drug reactions. It is therefore surprising that only a few cases of the neuroleptic malignant syndrome have been described in patients with the acquired immunodeficiency syndrome. A high index of suspicion is required to diagnose the neuroleptic malignant syndrome in these patients, as its usual manifestations, including fever and altered consciousness, are frequently attributed to an underlying infection.
感染人类免疫缺陷病毒的患者易发生多种感染性和非感染性并发症，且常接受多种药物治疗。此外，他们似乎对特异质性药物不良反应具有特殊易感性。因此，令人惊讶的是，获得性免疫缺陷综合征患者中仅报道了少数几例抗精神病药恶性综合征。在这些患者中诊断抗精神病药恶性综合征需要高度怀疑，因为其常见表现，包括发热和意识改变，常被归因于潜在感染。
