去铁胺治疗可减轻大鼠急性二氧化氮（NO₂）中毒后肺损伤的组织学证据。

Desferrioxamine treatment reduces histological evidence of lung damage in rats after acute nitrogen dioxide (NO2) intoxication.

Meulenbelt J, Dormans J A, van Bree L, Rombout P J, Sangster B

National Poison Control Centre, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.

Hum Exp Toxicol. 1993 Sep;12(5):389-95. doi: 10.1177/096032719301200508.

Abstract

In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO2 intoxication. 2. Desferrioxamine was administered intravenously to study its effect on histological alterations in lung tissue in rats after acute NO2 exposure. 3. Twenty four hours after exposure to 175 ppm NO2 for 10 minutes the lung injury observed by light microscopy in the desferrioxamine treated rats was less pronounced than in the saline treated rats. 4. Desferrioxamine appeared to provide more protection with a dose of 100 mg kg-1 24 h-1 than with 200 mg kg-1 24 h-1.

摘要

在先前的研究中，开发了一种大鼠吸入模型来研究急性二氧化氮中毒的治疗效果。2. 静脉注射去铁胺以研究其对急性二氧化氮暴露后大鼠肺组织组织学改变的影响。3. 在暴露于175 ppm二氧化氮10分钟后24小时，光镜下观察到去铁胺治疗的大鼠肺损伤比生理盐水治疗的大鼠轻。4. 去铁胺剂量为100 mg kg-1 24 h-1时似乎比200 mg kg-1 24 h-1时提供更多保护。