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A HTLV-I carrier who showed various symptoms and antibodies of autoimmune diseases.

作者信息

Mizuki M, Tagawa S, Shibano M, Okamoto Y, Nojima J, Sakata K, Takatsuki K, Kawata S, Hashimoto M, Hashimoto K

机构信息

Department of Clinical Research, Osaka University, Japan.

出版信息

Intern Med. 1993 Jun;32(6):449-54. doi: 10.2169/internalmedicine.32.449.

DOI:10.2169/internalmedicine.32.449
PMID:7902142
Abstract

We report a 37-year-old female HTLV-I carrier with complicating primary biliary cirrhosis (PBC) and mixed connective tissue disease (MCTD). Serum anti-HTLV-I antibody titer was x256. Flower cells (4.5%) were found in the peripheral blood. Southern blot analysis showed no clonal integration in peripheral blood lymphocyte (PBL) DNA. Polymerase chain reaction showed the HTLV-I genome in PBL DNA. As cholestatic liver dysfunction and serum titer of anti-mitochondrial antibody were found, a clinical diagnosis of PBC was made. This patient later developed MCTD. These diseases responded well to prednisone. The pathogenetic relationship of HTLV-I infection with various autoimmune diseases is discussed.

摘要

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