参与大鼠心房对去氧肾上腺素正性变力反应的α1-肾上腺素能受体亚型。
Alpha 1-adrenoceptor subtype involved in the positive inotropic response to phenylephrine in rat atria.
作者信息
Noguchi H, Muraoka R, Kigoshi S, Muramatsu I
机构信息
Second Department of Surgery, Fukui Medical School, Japan.
出版信息
Eur J Pharmacol. 1993 Aug 24;240(2-3):291-3. doi: 10.1016/0014-2999(93)90911-z.
Phenylephrine produced positive inotropic responses in isolated rat right and left atria. The responses were competitively inhibited by alpha 1-adrenoceptor antagonists (prazosin, WB4101 and HV723) with relatively low affinities (pA2 values close to 8.0). Chloroethylclonidine had no significant effect on the responses to phenylephrine. These results suggest that the positive inotropic response to phenylephrine in rat atria is mediated through alpha 1-adrenoceptors which cannot be defined by the alpha 1A, alpha 1B subclassification.
去氧肾上腺素可使离体大鼠右心房和左心房产生正性肌力反应。这些反应受到α1 - 肾上腺素能受体拮抗剂（哌唑嗪、WB4101和HV723）的竞争性抑制，亲和力相对较低（pA2值接近8.0）。氯乙可乐定对去氧肾上腺素的反应无显著影响。这些结果表明，大鼠心房对去氧肾上腺素的正性肌力反应是通过α1 - 肾上腺素能受体介导的，而不能用α1A、α1B亚型来定义。
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